Semaglutide
What is Semaglutide?
Semaglutide is a modified molecule our bodies make, called a GLP-1 analog. It works by increasing insulin production and lowers glucagon secretion as well as targets areas in the brain that regulate appetite and food intake. A small change in the molecule allows the drug to last weeks in our bodies rather than the natural version our bodies make, which lasts minutes.
How Does Semaglutide Work?
Semaglutide acts in the following ways:
- Delays how quickly our stomachs digest food, leading to a feeling of fullness and satisfaction with smaller meal sizes.
- Slows intestinal motility so you will feel fuller longer after meals.
- Lowers blood sugars, in part by reducing the production of sugar in the liver.
- Stimulates insulin secretion by the pancreas.
DOSING
Semaglutide Dosing Conversion Chart / STEP Trial Titration Schedule
Prescription WEEKS Strive Semaglutide/B12 Dose
Benefits of Semaglutide
- Decreased appetite and cravings
- Weight loss
- Improved blood glucose control
Side Effects/Contraindications
The most common side effects include nausea and constipation. * Patients also report acid reflux, stomach pain, vomiting, and diarrhea. The risk of serious side effects increases in patients with hypoglycemia, kidney problems, and risk of allergic reactions.
*1mg/mL of Cyanocobalamin added to reduce nausea side effects.
**This medication is not insulin and should not be used if you have type 1 diabetes or if you develop diabetic ketoacidosis. Semaglutide should not be used with any other GLP-1 medications.
RISK OF THYROID C−CELL TUMORS. If you or any family members have been diagnosed with Multiple Endocrine Neoplasia Syndrome Type 2 or Medullary thyroid cancer you should not take Semaglutide. If you have ever had pancreatitis consult with your medical provider as using Semaglutide can increase the risk of developing pancreatitis.
Who can take it?
You will likely be suitable for our Weight Loss Clinic if:
- You are an adult aged 18-75, with a Body Mass Index (BMI) of 30 or above (in the obese category).
- You are an adult aged 18-75, with a a BMI of 27 or above and have weight-related health issues) present including high blood pressure, high cholesterol or respiratory conditions such as sleep apnoea.
Please see the BMI Chart below for reference.
However, you will not be suitable for the Weight Loss Clinic if any of the following apply:
- You are pregnant or trying to get pregnant
- You have a personal history of multiple endocrine neoplasia (MEN
Syndrome) - You have a known hypersensitivity to the medication or any of the components
- You are under the age of 18 or over the age of 75
- You have been diagnosed with diabetes (type 1 or type 2)
- You have been diagnosed with a body image or eating disorder
Semaglutide sublingual drop is available now!
Semaglutide is a medication belonging to the class of drugs known as GLP-1 (glucagon-like peptide-1) receptor agonists. It is used for chronic weight management. It works by increasing insulin production and lowering glucagon secretion as well as targeting areas in the brain that regulates appetite and food intake. A small change in the molecule allows the drug to last weeks in our bodies rather than the natural version our bodies make, which lasts minutes.
Lowers blood sugar, in part by reducing the production of glucose in the liver
Decreases inflammation throughout the body, which leads to adiponectin release and fat lipolysis.
